Cannabidiol or CBD is a non psychoactive cannabinoid that comes from hemp and cannabis. It cant get you high, but can certainly perform some biochemical magic throughout your body. As you are about to see, there’s been increasing scientific inquiry into the vast benefits of CBD. This information stands to support the long touted anecdotal reports of CBD’s (and Cannabis) efficacy as a medicine.
Whilst cannabis research is still in its infancy, there’s some encouraging data accumulating that certainly warrants further investigation into CBD as a medicine. With this, the development of highly targeted cannabis based medicines is just around the corner.
The study of Cannabis has also given us new understandings of human physiology, through looking at the Endocannabinoid System (ECS). The ECS is a homeostatic regulator of neurotransmitter systems, and just about every other physiological system in the body. We use our own cannabinoids (endocannabinoids) to operate this system.
Since cannabinoids interact with the ECS in a similar manner to endocannabinoids; cannabis based medicines can have profound and diverse influences on human physiology and therefore health.
Here’s an idea of just how significant the impact of CBD is on physiology:
1. ADHD
When you think of attention deficit hyperactivity disorder, I bet you picture kids who find it tough to focus and be still. But, ADHD affects kids and adults. Anecdotally CBD is a promising therapy for kids and adults alike, encouraging stillness and focus on the task at hand: A randomised controlled trial found Sativex, a cannabinoid medication (1:1 CBD:THC) to significantly improve hyperactivity/impulsivity, attention and even cognitive ability in adults with ADHD. You can also get info on medicinal marijuana that shares the same 1:1 ratio, though it is not clear if the same results can be achieved.
2. Drug Addiction (Opioids)
To say the opioid epidemic is a ‘real’ problem is an understatement. Opioids have become a drug of abuse given their accessibility through prescriptions. In 2015 prescription opioids caused 15,000 deaths in the US alone. Thats not even including heroin. Its clear that those without access to the appropriate council or resources to deal with their psychological/physical pain, use opioids to treat it with addictive and deleterious consequences. CBD, a safe and therapeutic Cannabinoid may offer a reverse gateway from opioid addiction. A study found that rats who had free access to heroin did not alter their use with CBD. But, CBD did interrupt heroin use induced by a cue (in a human that would be an event provoking relapse). These affects lasted up to two weeks! This is promising for the prevention of heroin dependence and relapse.
3. Drug Addiction (Cocaine)
Since CBD has therapeutic, non hedonic properties it might be considered an intervention for stimulant and amphetamine addiction. Whilst it fails to reduce the rewarding qualities of these drugs, it may help support recovery from addiction and help prevent relapse.
4. Drug addiction (Nicotine)
Nicotine is one of the most addictive drugs, and is easily accessible throughout the world. In attempts to quit, efforts are frequently met with resistance and end up with a lit cigarette in hand for a lot of us. But, a randomised, double-blind, placebo-controlled study on 24 smokers who wished to stop smoking showed some promising results. A CBD inhaler vs placebo inhaler significantly reduced the number of cigarettes smoked during the week of treatment (~40%). There was even a reduction in cravings during the treatment week, and a reduction in cigarettes smoked in a two week follow up.
5. Cannabis Dependence
Prepare to be confused, this ones a real gem. Although highly medicinal, cannabis can be subject to abuse, like any drug. Cannabis use can become an issue when the person smoking it becomes dependent on it. Ironically, CBD might be useful in reducing this dependence given its opposing effects to THC, pharmacologically and behaviourally. A study tested 94 cannabis users when sober and when intoxicated, 7 days apart. Users who smoked higher CBD:THC cannabis showed a reduced draw to drug and food stimuli compared with smokers of higher THC:CBD cannabis. These results indicate CBD to reduce incentive for reward when a drug cue is presented.
6. Alzheimers
Most of us know Alzheimer’s to be a severe case of memory loss, starting short term and progressing into long term memory loss. Its a neurodegenerative disease which is characterised by the formation of plaques in the brain, impairment of brain cell signalling, inflammation of the brain and oxidative stress (antioxidants combat this). Conventional treatments are ineffective at stoping or reversing this disease (nutrition therapy and lifestyle changes are promising treatments). CBD is an exciting treatment option for Alzheimer’s because it is multifunctional – its an anti-inflammatory, antioxidant and a neuroprotective. These effects have been shown to reverse and prevent cognitive deficits in rats with Alzheimer’s Disease.
7. Crohn’s Disease
Crohn’s is a subtype of inflammatory bowel disease where the lining of the gut wall is chronically inflamed, as well as other functional abnormalities. Its often hard to digest certain foods without pain, bloating and erratic bowel movements. Interestingly, a clinical trial found Cannabis helped reduce inflammation and provided symptomatic relief in CD patients.
Another study using rats found CBD to reduce inflammation and functional abnormalities in CD, like motility (passage of food through GI tract). The effects of CBD were greater when combined with THC.
8. Irritable Bowel Syndrome
IBS shares symptoms with IBD, and might even exist along a spectrum where IBS is an early form of IBD. There are similar functional impairments in digestion, as well as chronic low grade inflammation. But generally, IBS is less severe and more common than IBD. This review suggested that a clinical endocannabinoid deficiency (CECD) is a developmental factor in IBS. Since medicinal cannabinoids like CBD help to modulate the endocannabinoid system, they may provide therapeutic benefits for IBS.
9. Depression
Depression is still treated symptomatically, with an emphasis on treating the ‘underlying chemical imbalance’. Neuroinflammation (inflammation of the brain) is thought to play a part in interfering with chemical signalling, producing these imbalances. Although depression is a psychospiritual affliction requiring more than just chemical adjustment, medicinal cannabinoids may still provide safe symptomatic relief. Because cannabinoids like CBD act through the endocannabinoid system, they can influence the release of neurotransmitters in the brain which regulate mood. When mice were injected with CBD, it enhanced the signalling of glutamate and serotonin producing fast acting antidepressant qualities. CBD also acts as a neuroprotective and anti-inflammatory in treating Alzheimer’s; it may act in a similar way for neuroinflamamtion in depression.
10. Type 1 Diabetes
T1D is an auto-immune condition where the Beta cells of the pancreas are unable to secrete sufficient insulin to regulate blood sugar. An overactive immune system attacks and damages these Beta-cells, inhibiting the function of the pancreas and secretion of insulin, creating the need to use external insulin. Amongst its myriad of other qualities, CBD is an immunomodualtor helping the immune system to cool off on the inflammation that is damaging the pancreas. A study on T1 diabetic mice found that CBD reduced levels of the proinflammatory cytokine IL-12, and significantly elevated levels of the anti-inflammatory cytokine, IL-10. This is an encouraging finding, supporting the therapeutic treatment of T1D with cannabinoids.
11. Type 2 Diabetes
T2D also occurs from pancreatic exhaustion, where cells in the body become resistant to the action of insulin when trying to store glucose. Beta-cells produce large amounts of insulin in an attempt to push glucose into insulin resistant cells. Eventually, Beta-cells are unable to maintain this insulin output. This creates the need for external insulin. Since endocanabinoids influence glucose and lipid metabolism, medical cannabinods may help to regulate blood sugar and insulin sensitivity.
Interestingly, an epidemiological study found that regular marijuana users showed lower levels of fasting insulin, as well as smaller waist circumference. This however may be an effect of THC more so than CBD. A randomised, double-blind, placebo-controlled group studyexamined the effects of THCV and CBD on patients with T2D. They found that THCV significantly decreased fasting plasma glucose, and and improved pancreatic β-cell function, and concluded THCV to be a therapeutic agent in glycemic control.
12. Fibromyalgia
13. Cardiac Arrhythmia
12 young people per week in the UK and 210,000 people per year in the US die from sudden cardiac arrest. Some are due to Ischemia-induced arrhythmias; a loss of ventricular blood flow, causing the heart to beat out of synchronisation. CBD has actually been shown to have a cardioprotective effect in both the short (acute) and chronic (long) phases of ischaemia. CBD does this by exerting an anti-arrhythmic effect, as well as sparing the tissues of the heart. This means CBD may exert therapeutic potential both before and after a heart attack.
14. Multiple Sclerosis
Affecting the spinal cord, nervous system and the brain, the symptoms of MS are often painful and affect co-ordination, balance, thinking, learning and planning. As a result, you can imagine that quality of life is drastically affected by such afflictions. But, Sativex, a cannabinoid medicine made from THC and CBD in a 1:1 mixture has been shown to effectively reduce neuropathic pain in those with MS.
In another study, Sativex reduced spasticity, sleep disturbances and muscle spasms seen in MS.
15. Chemotherapy Induced Nausea
When undergoing treatment for cancer, a well known and common side effect is the nausea and vomiting. In order to endure ongoing treatments, cannabis based medicines may provide a helping hand through the undesirable side effects of chemo. A phase II clinical trial using a combined THC/CBD preparation, when added to standard antiemetic therapy, compounded to provide better protection against delayed chemotherapy-induced nausea and vomiting.
16. Osteoporosis
In osteoporosis, bones become brittle, fragile and therefore susceptible to fractures. Due to nutrient deficiencies and hormonal changes, the activity of bone forming and degrading cells become disrupted. Cannabinoids are known to regulate bone mass, and can potentially support the healing and growth of bones. This study found that CBD enhanced the process of healing in rats with broken legs. CBD stimulated greater activity from osteoblasts (bone forming cells) and supported the process by which collagen repairs fractures.
17. Parkinsons
Parkinsons disease develops progressively, and is characterised by the degradation of dopaminergic neurones. Uncontrolled movements, difficulty moving and tremors are in part caused by this interruption in dopamine signalling. Since cannabinoids are neuroprotective, they may interrupt the progressive neurodegeneration in Parkinsons. A double blind trial found that 300mg CBD increased quality of life measurements in parkinsons patients. CBD did not show any significant difference for motor and general symptoms score or neuroprotection, though. However, combinations of THC and CBD may provide greater benefit since they act synergistically, and on more targets which may account for greater neuroprotective effects.
18. Post Traumatic Stress Disorder
PTSD, where traumatic events trigger a stress response from the brain throughout the nervous and endocrine system, can be damaging both psychologically and physiologically. Endocannabinoids share an interaction with glucocorticoids (stress hormones), which can reduce the severity of emotional memories. This study looked at individuals with PTSD after the world trade centre attack and found reduced levels of circulating endocannabinoids. This is much like the clinical endocannabinoid deficiency seen in IBS, Migraine and Fibromyalgia.
Cannabinoids may help here, as they dampen the experience of stress in the amygdala, hypothalamus and pre-frontal cortex of the brain. This has a calming effect throughout the body, making it easier to sleep and cope with PTSD. Medical cannabis is associated with reductions in PTSD symptoms, and cannabis resin provides antidepressant and fear extinction qualities.
19. Rheumatoid Arthritis
Rheumatoid Arthritis is another auto-immune condition, where joints become painful, inflamed, stiff and less mobile. CBD has actually been found to be beneficial in several ways: It helps reduce pain, reducing immune system over activation (immunosuppresive) and reduces inflammation in the joints.
20. Schizophrenia
Altered states of mind/personality in schizophrenia are chemically identified by dysregulation of neurotransmitters, and inflammation within the brain. Interestingly, the endocannabinoid Anandamide (an endocannabinoid neurotransmitter) is inversely correlated with psychotic symptoms in schizophrenia. CBD actually slows the degradation of anandamide, increasing its circulating levels. This has been shown to produce antipsychotic effects in schizophrenia when CBD is used.
21. Acne
The endocannabinoid system has a far reaching influence throughout the body, even extending as far as the skin. Believe it or not, your ECS can actually mediate cell growth and differentiation. When applied to a human skin culture, CBD showed several beneficial qualities which make it a promising therapeutic agent for Acne, one of them being its properties as an anti-inflammatory.
22. Psoriasis
Psoriasis is a skin condition which presents as sore, itchy, scaly patches of skin. These can crop up anywhere on the body, most commonly on limbs and the lower back. Psoriasis is another inflammatory condition, which can be mediated by the immune – anti-inflammatory properties of cannabinoids. There is also data showing the Endocannabinoid System to regulate growth, proliferation and death of skin cells. Therefore, cannabinoids may interact with the ECS to provide a therapeutic benefit. A study has shown cannabinoids to inhibit the multiplication of keratinocytes; the skin cells which spread rapidly in Psoriasis. This means that cannabinoids may be able to clinically manage psoriasis through reducing inflammation and inhibiting cell multiplication.
23. Insomnia
Cannabis is famous for its sleepy, relaxing qualities. For those who are in pain or chronically ill, its often tough to get the rest needed to heal. This opens the door for cannabis to not only maximise rest for illness, but also increase the quality of life associated with a good nights sleep. This case study reports clinical data of a girl with PTSD and anxiety who progressively improved her quality and quantity of sleep when given CBD oil. Also, a trial with a cannabinoid medicine, Sativex, using THC and CBD in a 1:1 ratio also shows great improvement in quality of sleep in patients with a variety of pain conditions. Additionally, there is little need to up the dosage as it remains effective without developing tolerance.
24. Cancer
A groundbreaking quality of cannabinoids is their influence on the formation and proliferation of cancerous cells. Cannabinoids are thought to have anti-tumour effects through the induction of a process called apoptosis. This is a controlled process by which cells are destroyed. Cannabinoids like CBD help to specifically programme the death of cancerous cells. There is also evidence that CBD influences a process called autophagy – a programmed cellular cleansing mechanism which degrades and recycles cellular components.
credit:420intel.com
